Pentoxifylline and Tocopherol in the Treatment of Osteoradionecrosis of Jaw – an Update
نویسندگان
چکیده
Osteoradionecrosis of jaw is one of the significant complications of radiotherapy in head and neck cancer patients. This article reviews pathophysiology and newer treatment options for osteoradionecrosis. Newer modalities of treatment include combination therapy of pentoxifylline and tocopherol for osteoradionecrosis. In this article basic information about pentoxifylline and tocopherol and recent reports of their clinical application in the treatment of osteoradionecrosis of jaw is reviewed. Literature Reports show that these drugs offer potentially curative therapy for osteoradionecrosis and requires further high quality clinical trial evaluation.
منابع مشابه
New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol
Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced. In this review article, we will discuss the definition and classifications of osteoradionecr...
متن کاملManagement of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series.
BACKGROUND Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON). METHODS Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antim...
متن کاملAdjunctive pentoxifylline and tocopherol (PENTO) in the treatment of medication-related osteonecrosis of the jaw (MRONJ): a prospective, randomized controlled trial to evaluate a novel non-operative treatment. PI:
Medication-related osteonecrosis of the jaws (MRONJ) is an uncommon, but serious, complication of anti-resorptive and anti-angiogenic medications in the management of osteoporosis and to limit skeletally related events in cancer patients. Oral and maxillofacial surgeons diagnose and manage MRONJ. We continue to find more medications that have potential to lead to osteonecrosis of the jaw and th...
متن کاملProphylactic Use of Pentoxifylline and Tocopherol in Patients Undergoing Dental Extractions Following Radiotherapy for Head and Neck Cancer
BACKGROUND In head and neck cancer patients undergoing radiotherapy, osteoradionecrosis (ORN) of the jaw is one of the major but uncommon complications. Satisfactorily results have been observed while treating ORN patients with upcoming treatment modalities such as combination therapy of pentoxifylline and Vitamin E (PVe). It is believed that in patients undergoing dental extractions, these tre...
متن کاملPentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.
BACKGROUND Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage. METHODS We report the case of a patient treated at our institution and present a review of the literature. RESULTS A 52-year-old woman presented with ORN of the temporal bone 20 years after radiation therapy for an ipsilateral parotid tumor. She failed con...
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